{\rtf1\ansi\ansicpg1252\cocoartf1404\cocoasubrtf470
{\fonttbl\f0\fswiss\fcharset0 Helvetica;}
{\colortbl;\red255\green255\blue255;}
\margl1440\margr1440\vieww10800\viewh8400\viewkind0
\pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural\partightenfactor0

\f0\fs24 \cf0 k_BT = 1.3806*10^\{-23\} J/K  300K = 1.3806*10^\{-23\}  6.02*10^\{-23\} * 300 J//mol = 2.5 kJ/mol = (2.5/4.182) kCal/mole \
Note: TABI energy unit is kCal/mol and APBS energy unit is kJ/mole thus if using TABI, we should use pK_a = (\\Delta G)*4.182/2.5/2.303 while APBS use pK_a=(\\Delta G)/2.5/2.303.}